inflammation (duration and severity of morning stiffness as measured by BASDAI). Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. , Rodrigues M One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). 2022 Sep;8(2):e002395. Can Lupus Patients Take the Driver's Seat in Their Disease Monitoring. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. et al. Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. Stojan G , Roberts WN Navarra SV et al. 1 2. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Reliability measures the reproducibility of the instrument: it refers to the degree of agreement between different observers (interrater) and in the same observer over time (intrarater). government site. , Devilliers H Devilliers H It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally. Beaton DE It does not provide a predefined or limited list of disease manifestations or organ systems, thus allowing one to capture all the heterogeneous aspects of SLE disease activity. Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study. The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. , Merrill JT. These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. A good correlation was considered for a value >0.60. It operates in Albuquerque, and New Mexico. , Mosca M Ward et al. Reviews and case series with fewer than five patients were excluded. , Holland M Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). For permissions, please email: journals.permissions@oup.com, This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (. Manzi S Once two investigators (E.C., M.P.) , Clowse M. Moorthy LN , Ibaez D Provide oversight to Shared Services Derivatives team supporting RWA operations and production. Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Supervise the development of junior medical affairs staff . In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. , Arbab-Zadeh A We have systematically reviewed all studies about validation of the PGA in SLE. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 CareerBuilder TIP. Cloud, mobility, security, and more. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). Conclusion: Epub 2014 Apr 11. et al. 2022 Jan 11;11(2):340. doi: 10.3390/jcm11020340. , Seaman AL Content validity. , Chatzidionysiou K et al. , Taghavi-Zadeh S Bookshelf et al. et al. Navarra SV Injuries requiring medical treatment are considered to be "reportable incidents," and must be reported to the NJDOE within five working days of the occurrence. In 32 studies, disease activity measured by PGA was compared with changes in laboratory markers, with the aim of correlating clinical and serological features [9, 21, 30, 32, 34, 3739, 44, 45, 48, 49, 55, 5861, 63, 64, 66, 67, 69, 71, 74, 75, 82, 86, 89, 9194]. Rheumatology (Oxford). The PGA is a valid instrument but has variable reliability; its scoring should be standardized. Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. , Landis RC The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. , Petri MA , Magder LS Barr et al. The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. RMD Open 2018;4:e000578. Glossary: PGA. , Urowitz MB. Physician's Global Assessment Scale (PGA) or Investigator's Global Assessment Scale (IGA) measures disease status in a broad range of diseases. Presence of at least one of the following items of serological evidence of active SLE or biological variables predictive of Type 1 Interferon (IFN-1) high signature (in a Screening sample as measured by central laboratory): In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study . The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). , Tugwell P Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). Published by Oxford University Press on behalf of the British Society for Rheumatology. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) , Ko T et al. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. , McGwin G Annapureddy N In one study [25], the PGA of disease activity resulted from the combination of the clinical visit, laboratory markers evaluation and the physicians knowledge of the patient disease history. Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). may be asked to hyperventilate 3-4 min and watch a bright flashing light. Lai J-S Sullivan KE The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , OMalley T , Suriano A The literature search identified 91 studies. et al. et al. The aim of this systematic literature review is to describe and analyse the . , Kalunian K Mina R , Matos A Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). Brunner HI , Guzmn RM The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . et al. Would you like email updates of new search results? et al. Franklyn K , Zonana-Nacach A It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. , Magder LS Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. sharing sensitive information, make sure youre on a federal global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . This important heterogeneity in the anchoring of the PGA prevented us from performing a meta-analysis of reliability data. . Responsiveness. , Mohan C. Giangreco D Patient-Reported Outcomes in Systemic Lupus Erythematosus. Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. et al. Careers. doi: 10.1136/rmdopen-2022-002395. , Engleman EG Methods We determined the variability of MD globals, surveying rheumatologists from the Canadian Rheumatology Association using rheumatoid . J Clin Med. Systemic lupus erythematosus (SLE), is the most common type of lupus. National Library of Medicine In Fatemi et al. et al. et al. Federal government websites often end in .gov or .mil. Published by Oxford University Press on behalf of the British Society for Rheumatology. Unable to load your collection due to an error, Unable to load your delegates due to an error. , Larson MG This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. et al. , Carpenter AB , Khamashta MA Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Touma Z COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Your comment will be reviewed and published at the journal's discretion. Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Mikolaitis-Preuss RA lupus erythematosus; systemic outcome assessment; qualitative research; healthcare; We read with great interest the recent paper by Aranow et al 1 about the impact of laboratory results on scoring of the Physician Global Assessment (PGA) of disease activity in systemic lupus erythematosus (SLE). Fanouriakis A PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. Notorious to increase IOP and cause severe PAIN and headache; Diagnostics: - History - Tonometry examinations - measures IOP QUESTION A client states that the physician has told her that her intraocular was 14. Schneider M Different definitions of disease activity according to the PGA instrument. The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). , Su J Jesus D Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . , Wetter J The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. Epub 2014 Jul 10. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. , Piette EW , Emamikia S A good responsiveness for PGA was shown in eight studies. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). ~SLE~. All versions are validated and used by lupus researchers for clinical and research purposes. , Esdaile JM. All rights reserved. A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. van Vollenhoven R This site needs JavaScript to work properly. , Maxwell LJ , Raeisi A Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. Forbess LJ Changes in the PGA correlated with changes of other disease activity indices (SLEDAI, SLAM, LAI, patient global assessment), laboratory exams (ESR), patient-reported outcomes (Lupus Impact Tracker) [23, 50, 58, 77, 78, 81, 83] and response to treatment [4]. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. Gordon C HHS Vulnerability Disclosure, Help , Dyer JW X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. et al. , Sengupta M , Bouter LM , Mina R , Petri M. Iaccarino L Strength. , Bresee C 1), accounting for 49 longitudinal cohort studies, 25 cross-sectional studies, 7 randomized controlled trials, 3 consensus conferences, 4 post-hoc analyses, 2 retrospective studies and 1 case series. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. Arriens C et al. Data regarding divergent validity are lacking for the PGA. On stratifying the results by individual clinician, values ranged from 0.61 to 0.90, except for those reported by . AU - Louthrenoo, Worawit. , Gomez A Akhter E et al. Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. , Petri M. Foering K This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. , Petri MA The Physician's Global Assessment (PhGA) is a number without unit. MeSH The random effects model gives a more conservative estimate considering the heterogeneity. In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. et al. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). The .gov means its official. watch for seizures after the procedure. , Vogel-Claussen J Observed and articulated management issues and responses. Liang MH The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . 2) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99], with the SLAM in 4 studies (r=0.470.65) [35, 76, 84, 99], with LAI in 2 studies (r=0.640.75) [68, 84], with BILAG in 2 studies (r=0.610.62) [35, 84] and with ECLAM in 2 studies (r=0.580.65) [35, 84]. Face validity. et al. Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. , Bonithon-Kopp C Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). Karol DE PGA is an important tool for assessing disease activity, response to treatment (it is a component . The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . Pincus and colleagues conducted a study of . Parodis I et al. SLE3. PGA is often assessed by a single question with a 0-10 or 0 . No study has evaluated the feasibility of the PGA in SLE to date. et al. Moher D It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. [8] suggested that the PGA should account for objective examination, laboratory results and what patients report. , Klein-Gitelman MS Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . Int J Environ Res Public Health. The index has proved quick and easy to use despite a comprehensive database and compares favourably with . , Rairie JE , Jolly M. Ribi C Several definitions of minimum clinically important difference were retrieved: in the SRI-4, a significant worsening was defined as an increase of >10% on the PGA-VAS [111], corresponding to 0.3 points from baseline; Touma et al. The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. official website and that any information you provide is encrypted , Navarra SV This property is reported across all articles selected through this systematic review [24, 913, 21103]. BICLA is a validated composite global measure of SLE disease activity including SLEDAI-2K, CLASI-A, OCS dosage reduction, and patient-reported outcomes. Correlations with other instruments measuring similar constructs should typically demonstrate a coefficient (r) 0.50 [106]. , McGuire JL. et al. This concept includes content validity, face validity, construct validity and criterion validity. Oxford University Press is a department of the University of Oxford. . Myelogram - correct answer NPO for 4-6 hours. , Cella D. van Vollenhoven RF The OMERACT defines an instrument as an outcome measure if it passes the three pillars of evidence: truth (that refers to validity), discrimination (that includes reliability and responsiveness) and feasibility. physician global assessment Recently Published Documents. Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. PGA is often assessed by a single question with a 0-10 or 0-100 response. FOIA Merrill JT The site is secure. AU - Kandane-Rathnayake, Rangi. , ODell JR , Socher SA In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. The Author(s) 2020. The literature search identified 91 studies. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). An international panel of 79 SLE experts participated in a three-round Delphi consensus . Methods: , Block JA , Altman DG Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Gladman DD Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. This button displays the currently selected search type. Mok CC , Patrick DL 215 (FIVE YEARS 146) H-INDEX. Disagreements between investigators were solved by consensus. Results. A good responsiveness for PGA was shown in eight studies. et al. Piga M , Glassman DS Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). , Ogale S , Nelson S (PGA)and physician global assessment of disease activity (PHGA), C3, C4 and Anti-ds Anti-DNA titer abnormalities, and a formula incorporating the current . Mok CC Few studies reported on whether serological activity should be incorporated in the PGA. AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . , Sjwall C For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Barr SG Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. Of note, the literature search revealed heterogeneous definitions of physician assessment of disease activity other than the PGA (physician global assessment [4, 70, 73], physician overall assessment [85]). , Hochberg M. Touma Z et al. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . , Sjwall C. Strand V et al. Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. , Adamichou C Wells GA et al. [35], the PGA correlated, although moderately, with the need for treatment change (r=0.46, P<0.01). 2014 - 20184 years. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. et al. and transmitted securely. , Ho LY Petri M , Brunetta P , Schirmbeck LA The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . Copay AG et al. The last MEDLINE search was performed on 1 July 2019. , Petri M. Isenberg DA , Borghoff K The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. et al. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 Reliability. Liang et al. , Saad-Magalhes C , Fang H et al. SFI, LLDAS, SRI, Definitions of Remission in Systemic Lupus Erythematosus remission criteria) [3, 5, 10, 1315, 104]. , Terwee CB Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. More frequently, responsiveness was assessed by correlating changes in the PGA with changes in other scores [23, 50, 58, 77, 78, 81, 83], finding a significant correlation with variations in the SLEDAI (r=0.390.66) [23, 77, 78], SLAM (0.61) [77], LAI (0.56) [77], patient global assessment (0.37) [77], SRI-50 (0.48) [78] and ESR (P<0.0001) [58], but not with C3, C4, circulating immunocomplexes and prednisone dose [77]. , Askanase A , Siega-Riz AM , Hearth-Holmes M. Khan A , Andreoli L , Urowitz MB Bethesda, MD 20894, Web Policies Parodis I In the second column, the definitions were reported according to the VAS used in the study. BICLA responders had fewer lupus-related serious . , Koutsoviti S , Burlingame RW et al. The PGA was developed on a 0 to 3 scale as part of the Lupus Activity Index.

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