There is no specific "diet" for people with factor V Leiden, but there are foods that can help keep your blood and body healthy, which may reduce your risk of developing a blood clot. No foods can change your genetics, but having the right type of diet may prevent your condition from getting worse. Gluten-free: The breads Pasternak allows are flour-free. One or both of the factor V genes can be mutated and cause the altered form of the factor V protein known as the Factor V Leiden protein to be made. This content does not have an English version. HW}Wc)h"Y$ x N,@I)T7;&?/s"C0]=wSb;{PlYdA&Trb"agbH0Hok8bio@k'q More info. Factor V Leiden is the most common one. Compilation of the top interviews, articles, and news in the last year. Factor V and other proteins work together to help your blood clot when necessary. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. As they come, write them down. In 2010 I was pregnant with my son. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. It is important to note that alcohol also has some anticoagulant action and can protect adults from blood clots, although it is not recommended as a preventative measure for this purpose. Stand up and walk around during long flights. Going on a long flight or a very long road trip. Deep venous thrombosis (DVT). If excess vitamin K is taken, it is stored for future use in the liver. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. 3. There is also a 50% chance that your child will inherit your normal Factor V gene. As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. Following your providers guidance can help you catch and resolve problems early before they interrupt the flow of your life. People with Factor V Leiden make an altered factor V protein as a result of a mutated gene. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, Thomas SH, eds. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). 2019. Genetic and Rare Disease Information Center. Where's the Health Benefit? In a worst-case scenario, it lands in your legs, leading to deep vein thrombosis, or your lungs, forming a pulmonary embolism. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. Are young and healthy when you get a clot. The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health. Eat well. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Individuals who happen to know that they have factor V Leiden but have never had blood clots dont have to be prescribed any blood thinners. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. Pasternak, H. The 5-Factor Diet, Ballantine Books, 2009. diabetes.org: "Glycemic Index and Diabetes. Talk with your doctor about the risks and benefits of taking these medications. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. We inherit one gene from our mother and one from our father. Want to talk about Multiple Myeloma: Anyone else? Mayo Clinic, Rochester, Minn. June 17, 2018. <]>> Mayo Clinic does not endorse companies or products. Here's some information to help you prepare for your appointment. of signs you need emergency medical attention or call 911. High-Protein Diets -- Do They Really Work? Please note that medical information found A variety of herbs and vitamins may interact with anticoagulants. Make a donation. If you cant walk around, flex your ankles and point your toes up and down. 0000003553 00000 n Check with your provider. 2. The clotting action of Factor V is controlled by another protein called Activated Protein C. To stop blood from forming clots, Activated Protein C easily turns off Factor V. Activated Protein C does not work as well on the abnormal Factor V Leiden protein. (2019, May 20). Fortunately, about 95 percent of people with this condition never develop a clot, according to the National Institutes of Health. Accessed June 4, 2018. At least 1 of the genes that you inherited is the mutated gene that makes the Factor V Leiden protein. Accessed June 4, 2018. The Meat Effect: Protein, Carbs, and Your Diet. Vegetarians and vegans: You can easily modify the 5-Factor Diet for vegetarian and vegan diets, though the protein sources for vegans are somewhat limited. https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. You probably wont know you have prothrombin gene mutation unless you have a specific blood test if/after you develop a deep vein thrombosis or pulmonary embolism. Creator and celebrity fitness trainer Harley Pasternak says it's a lifestyle plan, not a diet. I WAS DIAGNOSED IN MARCH OF THIS YEAR AFTER HAVING MY 2ND PULMONARY EMBOLISM. U.S. National Institutes of Health, National Library of Medicine. Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. This content does not have an Arabic version. It has been suggested as a risk factor for RPL as it triggers thrombophilia and impairs the initial vascularization process at implantation [ 6 ]. Factor V Leiden is the name of one such blood clotting disorder. Accessed June 4, 2018. Inherited thrombophilias in pregnancy. No, you cant prevent this blood clotting disorder. Do I need to take medication to prevent additional blood clots? What are my risks? Usually, once the clot is formed, factor V is "turned off," but not in those with factor V Leiden. Lose weight (if you have overweight/obesity). Cost: Just your groceries. We do not endorse non-Cleveland Clinic products or services. The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: Advertisement 1. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. Advertising revenue supports our not-for-profit mission. However, some people with this disorder develop DVT or PE. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. Enjoy a variety of foods from the 4 food groups. Take frequent breaks during long car rides to get out and stretch your legs. between patient and physician/doctor and the medical advice they may provide. If you or a loved one have factor V Leiden, you might feel scared about what the future will bring. Or maybe youve had no issues, but your loved one needed treatment for DVT. Symptoms of deep vein thrombosis in your arm or leg include: Symptoms of a pulmonary embolism (located in your lung) include: It is a genetic mutation in your Factor II gene that makes it create too much prothrombin (coagulation factor II), and you end up with a higher risk of developing blood clots than someone with a normal prothrombin gene. The mutation does not cause any symptoms in and of itself. Factor V Leiden makes you more likely to develop: Its important to know that people with factor V Leiden wont necessarily develop DVT or PE. It may ease your mind to know that most people with this disorder never have a blood clot. There is no treatment that can prevent this disorder or make it go away. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Having additional genetic blood clotting disorders. In general, you should avoid: You can help lower your risk of blood clots with lifestyle changes, including: Visit your provider for a yearly checkup. Vitamin K is found in the following foods: Flaxseed may inhibit the proper absorption of anticoagulants. If you have the prothrombin gene mutation but never had a deep vein thrombosis or pulmonary embolism before, you will not need a blood thinner during or after pregnancy. This site is not designed to and does not provide medical advice, Because its an inherited condition, you cant prevent the prothrombin gene mutation. In: Williams Hematology. You may substitute gluten-free alternatives as long as they are low-sugar. A single copy of these materials may be reprinted for noncommercial personal use only. Most notably, you will need to be aware of your vitamin K consumption. This is caused by a change (mutation) in the gene for this protein. Factor V Leiden thrombophilia. 0000007946 00000 n If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Avoid playing contact sports or engaging in other activities that could result in physical injury. Blood clots in less commonly affected veins, like those in your liver or brain. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. It even tells you what staples to keep on hand so you will always be able to get a quick meal together. But your provider can help you keep your blood from clotting too much. 0000229756 00000 n Factor V is a protein that is needed for blood to clot properly. Your healthcare provider may suspect you have factor V Leiden if you have a history of venous thromboembolism. This means that for children with factor V Leiden, one out of 5,000-10,000 will get a blood clot. Factor V Deficiency Vs. You may have a higher risk of getting: Pulmonary embolism. In fact, the vast majority (9 out of 10) never develop abnormal blood clots. Zoppi, Lois. Mayo Clinic is a not-for-profit organization. Check with your doctor or dietitian first. Medications to treat this condition may require dietary restrictions. Vitamin K is a necessary element in the blood clotting process. If you have factor V Leiden, you may have many questions. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . Talk to your provider to see if you should be taking a blood thinner. 0000236831 00000 n In situations where there is a greater chance of clotting (such as surgery, a leg cast, a serious illness or pregnancy) you may be treated with blood thinners until the risk has passed. News-Medical. Prothrombin G20210A (Factor II Mutation) Resources. This site complies with the HONcode standard for trustworthy health information: verify here. Soybean oil or soybean milk, as well as liver, has high vitamin K content, which may interfere with the action of VKAs. It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. If you have symptoms of a pulmonary embolism, you should go to the closest emergency room. You should either contact your provider or go to the nearest Emergency Room if you think youre having a deep vein thrombosis. 0000007474 00000 n But you should talk to your provider about what you can expect in your individual situation. As a result, too much blood clotting can happen. Limitations: You can eat anything you want on your weekly cheat day." Accessed June 4, 2018. A genetic mutation (change) causes factor V Leiden. Just by eliminating junk food, simple carbs, and high-calorie drinks, as in the 5-Factor Diet, most people are likely to see a dip on the scale. If you have the heterozygous type, there is a 50% chance that your child will inherit a Factor V Leiden gene from you. INR values of between 2.0 and 3.0 are considered effective therapeutic values while on anticoagulant therapy. This can be a life-threatening situation. 0000001564 00000 n When you are ready, talk with your health care provider for advice and help to stop smoking. If you have the disorder, you may never develop a blood clot. Laboratory testing (blood tests) diagnose this disorder. Factor V Leiden is a mutation of the genes that causes impairment to the normal process of blood clotting. What types of side effects can I expect from the medication? If you are experiencing serious medical symptoms, please see the Having Factor V Leiden does not appear to increase the chances of developing a heart attack or stroke. About 1 in every 50 white people in Europe and North America has the heterozygous prothrombin gene mutation, making it the second most common inherited clotting disorder. Hormones and birth control pills also increase womens risk of blood clots. Your body has many different proteins that do this work. "Anticoagulant Food-Drug Interactions". Its important to go to all of your appointments and talk to your provider about any questions or concerns you have. This helps your mood and gives you energy all day long. Factor V is a helper in the enzyme reactions that form the fibrin in the clot. (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). This test looks at how quickly the blood clots. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. Others can be life-threatening. endstream endobj 77 0 obj<> endobj 79 0 obj<>/Font<>>>/DA(/Helv 0 Tf 0 g )>> endobj 80 0 obj<> endobj 81 0 obj<>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>> endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj[/ICCBased 102 0 R] endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<>stream Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. Results from the PT test are expressed as a ratio called the international normalized ratio (INR). Chan School of Public Health. But some people inherit mutated versions of this gene and develop a condition called factor V Leiden thrombophilia. 0000006483 00000 n You may be treated with blood thinners until the risk has passed. As a result, your blood may clot more easily than it should, leading to serious complications. Kaushansky K, et al., eds. In most people, a protein called activated protein C regulates the activity of . If you do, another blood test that examines your genes (called DNA) will be done to find out if Factor V Leiden is the cause of the resistance and what type of Factor V Leiden you have. Whole grains: Choose whole grains like whole-grain bread, quinoa, farro and brown rice rather than refined grains, such as white bread, white rice, crackers and baked goods made with white flour. small children have a risk of 1 in 100,000 per year, those in their twenties have a risk of 1 in 10,000 per year, by age 40, this risk is 1 in 1,000 per year. Mango and St. Johns wort are also clinically relevant inhibitors of VKAs. Foods containing trans fat, including hydrogenated oils and highly processed shelf-stable food (think: packaged snacks and baked goods). You can have a family history of deep vein thrombosis (DVT) or pulmonary embolism (PE) but never develop either yourself. In this interview, we speak to Ceri Wiggins, a Director at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies. The amount of weight that you can lose, however, depends on many things, including your size, gender, and activity level. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). The latest information about heart & vascular disorders, treatments, tests and prevention from the No. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. Lockwood CJ, et al. How does prothrombin gene mutation affect my body? Should people with Factor V Leiden avoid Vitamin K? 2. Dont buy ones from the store or wear them without talking to your provider first. Factor V Leiden Information for Patients and Families Factor V Leiden is a blood clotting disorder. The factor V Leiden mutation changes this proteins structure. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Self-care therapies to support your reproductive health; PO Box 825687 These conditions can be life-threatening and require immediate medical treatment. You should know the warning signs of a problematic blood clot so you can identify it and get help. However, there are things that you can do to reduce your chances of developing a dangerous blood clot. If you want to increase the amount you're eating, your doctor can help you make the adjustment slowly, with appropriate adjustments to your medication. The different gene that makes the Factor V Leiden protein is inherited from one or both parents. All rights reserved. This content does not have an English version. This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. 2005 - 2023 WebMD LLC. There needs to be a balance of these proteins to make sure there is just enough clotting power: Factor V is one of the proteins needed to make blood form clots. Factor V Leiden thrombophilia. Prevention and Treatment of Excessive Blood Clotting (Hypercoagulation). The Factor V Leiden protein is harder to turn off than the normal Factor V protein. Clotting Disorders. Is this an emergency? They are prescribed to avoid the development of harmful blood clots. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . 0000008077 00000 n Factor V Leiden follows an autosomal dominant inheritance pattern. What are the chances of passing down the genetic mutation to my children? %PDF-1.5 % With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. The disorder is most common in people who are white and of European descent. Make a donation. Factor V Leiden resists the effects of Activated Protein C, so it takes longer to turn off Factor V Leiden. 8( x@YB.X0v@+::0Xv|@Q-s4>p03(/` `F0.oCD8}.n)2`b#jPv!A CPt k*6@)V+`b@@\crT0. Cranberry juice and other cranberry products can alter the effects of anticoagulants. WebMD does not provide medical advice, diagnosis or treatment. You may not need to do anything other than lead a healthy lifestyle to minimize the risk of a deep vein thrombosis or pulmonary embolism. NBCA provides the information and materials on this site for general information purposes only. The Top 5 Worst Foods for Your Heart, According to a Dietitian. You inherited one Factor V Leiden gene from your mother and one from your father. 0 Accessed June 4, 2018. %%EOF Often, those treatments will require hospitalization. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). Miscarriages associated with factor V Leiden are more likely to occur later in pregnancy (after the first trimester). If your provider feels its warranted, theyll order blood tests, including: Simply having a family history of blood clots may not be reason enough to run these tests. You may be treated with blood thinners during this time.

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